|
|
|
|
||
        |  |
 |
|
|
 |
|
 |
||||||||
|
||||||||||
|
|
|
|
|||||||
|
||||||||||
|
Graphical contents list • MISCELLANEOUS PDF (589 K) | |||
|
Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains • SHORT COMMUNICATION Timothy A. Blizzard, Frank DiNinno, Jerry D. Morgan, II , Helen Y. Chen, Jane Y. Wu, Candido Gude, Seongkon Kim, Wanda Chan, Elizabeth T. Birzin et al. SummaryPlus | Full Text + Links | PDF (271 K) | |||
|
Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains • SHORT COMMUNICATION Timothy A. Blizzard, Frank DiNinno, Jerry D. Morgan, II , Jane Y. Wu, Helen Y. Chen, Seongkon Kim, Wanda Chan, Elizabeth T. Birzin, Yi Tien Yang et al. SummaryPlus | Full Text + Links | PDF (263 K) | |||
|
Synthesis of benzoylpyrimidines as antagonists of the corticotropin-releasing factor-1 receptor • SHORT COMMUNICATION Thomas R. Webb, Terry Moran, Charles Q. Huang, James R. McCarthy, Dimitri E. Grigoriadis and Chen Chen SummaryPlus | Full Text + Links | PDF (284 K) | |||
|
Privileged scaffolds for blocking protein–protein interactions: 1,4-disubstituted naphthalene antagonists of transcription factor complex HOX–PBX/DNA • SHORT COMMUNICATION Tao Ji, Madison Lee, Steven C. Pruitt and David G. Hangauer SummaryPlus | Full Text + Links | PDF (301 K) | |||
|
Synthesis and antibacterial activity of arylpiperazinyl oxazolidinones with diversification of the N-substituents • SHORT COMMUNICATION Sun-Young Jang, Young Hwan Ha, Seung Whan Ko, Wonku Lee, Jongkook Lee, Sunghoon Kim, Yong Woo Kim, Won Koo Lee and Hyun-Joon Ha SummaryPlus | Full Text + Links | PDF (244 K) | |||
|
Synthesis and biological activity of 22-oxa CD-ring modified analogues of 1 ,25-dihydroxyvitamin D3: cis-perhydrindane CE-ring analogues • SHORT COMMUNICATIONSamuël Demin, Dirk Van Haver, Maurits Vandewalle, Pierre J. De Clercq, Roger Bouillon and Annemieke Verstuyf SummaryPlus | Full Text + Links | PDF (278 K) | |||
|
Synthesis and biological activity of 22-oxa CD-ring modified analogues of 1,25-dihydroxyvitamin D3: spiro[5.5]undecane CF-ring analogues • SHORT COMMUNICATION Wim Schepens, Dirk Van Haver, Maurits Vandewalle, Pierre J. De Clercq, Roger Bouillon and Annemieke Verstuyf SummaryPlus | Full Text + Links | PDF (282 K) | |||
|
Synthesis of symmetrical bis-alkynyl or alkyl pyridine and thiophene derivatives and their antiangiogenic activities • SHORT COMMUNICATION Chan Mug Ahn, Woon-Seob Shin, Ho Bum Woo, Seokjoon Lee and Hyean-Woo Lee SummaryPlus | Full Text + Links | PDF (270 K) | |||
|
Detection of DNA hybridization on a liposome surface using ultrasound velocimetry and turbidimetry methods • SHORT COMMUNICATION Tibor Hianik, Peter Rybar, Sergej Yu. Andreev, Tatiana S. Oretskaya and Pankaj Vadgama SummaryPlus | Full Text + Links | PDF (278 K) | |||
|
Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts • SHORT COMMUNICATION Chitalu C. Musonda, Dale Taylor, Julie Lehman, Jiri Gut, Philip J. Rosenthal and Kelly Chibale SummaryPlus | Full Text + Links | PDF (265 K) | |||
|
4-Acylamino-6-arylfuro[2,3-d]pyrimidines: potent and selective glycogen synthase kinase-3 inhibitors • SHORT COMMUNICATION Yutaka Maeda, Masato Nakano, Hideyuki Sato, Yasushi Miyazaki, Stephanie L. Schweiker, Jeffery L. Smith and Anne T. Truesdale SummaryPlus | Full Text + Links | PDF (309 K) | |||
|
A convenient and biogenetic type synthesis of few naturally occurring chromeno dihydrochalcones and their in vitro antileishmanial activity • SHORT COMMUNICATION Tadigoppula Narender, Shweta and Suman Gupta SummaryPlus | Full Text + Links | PDF (253 K) | |||
|
Intrinsic factor-mediated modulation of cyanocobalamin–N-sulfonyl-acridinium-9-carboxamide chemiluminescence • SHORT COMMUNICATION Maciej Adamczyk, Donald D. Johnson, Phillip G. Mattingly, Jeffrey A. Moore and You Pan SummaryPlus | Full Text + Links | PDF (522 K) | |||
|
Antituberculous activity of some aryl semicarbazone derivatives • SHORT COMMUNICATION Dharmarajan Sriram, Perumal Yogeeswari and RathinasabapathyThirumurugan SummaryPlus | Full Text + Links | PDF (229 K) | |||
|
Preparation of novel aza-1,7-annulated indoles and their conversion to potent indolocarbazole kinase inhibitors • SHORT COMMUNICATION Rima S. Al-awar, James E. Ray, Kyle A. Hecker, Sajan Joseph, Jianping Huang, Chuan Shih, Harold B. Brooks, Charles D. Spencer, Scott A. Watkins, Richard M. Schultz et al. SummaryPlus | Full Text + Links | PDF (289 K) | |||
|
Synthesis and structure–activity relationships of 1,5-diazaanthraquinones as antitumour compounds • SHORT COMMUNICATION Carmen Avendaño, José María Pérez, M del Mar Blanco, Jesús Ángel de la Fuente, Sonia Manzanaro, María Jesús Vicent, María Jesús Martín, Nélida Salvador-Tormo and J. Carlos Menéndez SummaryPlus | Full Text + Links | PDF (290 K) | |||
|
Cinnamic acid esters as potent inhibitors of fungal 17 -hydroxysteroid dehydrogenase––a model enzyme of the short-chain dehydrogenase/reductase superfamily • SHORT COMMUNICATIONStanislav Gobec, Matej Sova, Katja Kristan and Tea Lani SummaryPlus | Full Text + Links | PDF (260 K) | |||
|
Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues • SHORT COMMUNICATION Richard L. Jarvest, Sula A. Armstrong, John M. Berge, Pamela Brown, John S. Elder, Murray J. Brown, Royston C. B. Copley, Andrew K. Forrest, Dieter W. Hamprecht, Peter J. O'Hanlon et al. SummaryPlus | Full Text + Links | PDF (271 K) | |||
|
Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists • SHORT COMMUNICATION Charles Q. Huang, Keith M. Wilcoxen, Dimitri E. Grigoriadis, James R. McCarthy and Chen Chen SummaryPlus | Full Text + Links | PDF (276 K) | |||
|
Synthesis and biological evaluation of flavonoids as vasorelaxant agents • SHORT COMMUNICATION Zhiwei Chen, Yongzhou Hu, Haohao Wu and Huidi Jiang SummaryPlus | Full Text + Links | PDF (259 K) | |||
|
Oxamides as novel NR2B selective NMDA receptor antagonists • SHORT COMMUNICATION Gizella Barta-Szalai, István Borza, Éva Bozó, Csilla Kiss, Béla Ágai, Ágnes Proszenyák, György M. Keser SummaryPlus | Full Text + Links | PDF (268 K) | |||
|
Solution phase parallel synthesis and evaluation of MAPK inhibitory activities of close structural analogues of a Ras pathway modulator • SHORT COMMUNICATION Yingchun Lu, Sukumar Sakamuri, Quin-Zene Chen, Yen-Fang Keng, Vladimir Khazak, Katrin Illgen, Silke Schabbert, Lutz Weber and Sanjay R. Menon SummaryPlus | Full Text + Links | PDF (313 K) | |||
|
Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype • SHORT COMMUNICATION Carsten Hocke, Olaf Prante, Stefan Löber, Harald Hübner, Peter Gmeiner and Torsten Kuwert SummaryPlus | Full Text + Links | PDF (264 K) | |||
|
Himbacine analogs as muscarinic receptor antagonists––effects of tether and heterocyclic variations • SHORT COMMUNICATION Samuel Chackalamannil, Darío Doller, Robert McQuade and Vilma Ruperto SummaryPlus | Full Text + Links | PDF (260 K) | |||
|
Lysine sulfonamides as novel HIV-protease inhibitors: N -disubstituted ureas • SHORT COMMUNICATIONBrent R. Stranix, Gilles Sauvé, Abderrahim Bouzide, Alexandre Coté, Guy Sévigny, Jocelyn Yelle and Valérie Perron SummaryPlus | Full Text + Links | PDF (287 K) | |||
|
Rhodanine-3-acetic acid derivatives as inhibitors of fungal protein mannosyl transferase 1 (PMT1) • SHORT COMMUNICATION Michael G. Orchard, Judi C. Neuss, Carl M. S. Galley, Andrew Carr, David W. Porter, Phillip Smith, David I. C. Scopes, David Haydon, Katherine Vousden, Colin R. Stubberfield et al. SummaryPlus | Full Text + Links | PDF (261 K) | |||
|
Aza-boronic acids as non--lactam inhibitors of AmpC--lactamase • SHORT COMMUNICATION Valentina Buzzoni, Jesus Blazquez, Stefania Ferrari, Samuele Calò, Alberto Venturelli and M. Paola Costi SummaryPlus | Full Text + Links | PDF (316 K) | |||
|
Synthesis, characterization, and direct aqueous superoxide anion scavenging of a highly water-dispersible astaxanthin-amino acid conjugate • SHORT COMMUNICATION Henry L. Jackson, Arturo J. Cardounel, Jay L. Zweier and Samuel F. Lockwood SummaryPlus | Full Text + Links | PDF (403 K) | |||
|
5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3′-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity • SHORT COMMUNICATION Jeffrey R. Roppe, Bowei Wang, Dehua Huang, Lida Tehrani, Theodore Kamenecka, Edwin J. Schweiger, Jeffery J. Anderson, Jesse Brodkin, Xiaohui Jiang, Merryl Cramer et al. SummaryPlus | Full Text + Links | PDF (260 K) | |||
|
Analogs of sub-nanomolar hMC1R agonist LK-184 [Ph(CH2)3CO-His- L. N. Koikov, F. H. Ebetino, M. G. Solinsky, D. Cross-Doersen and J. J. Knittel SummaryPlus | Full Text + Links | PDF (271 K) | |||
|
Aptamer selection for the inhibition of cell adhesion with fibronectin as target • SHORT COMMUNICATION Atsushi Ogawa, Naotoshi Tomita, Naoko Kikuchi, Shinsuke Sando and Yasuhiro Aoyama SummaryPlus | Full Text + Links | PDF (406 K) | |||
|
Quantitative structure–activity relationship analysis of a series of 2,3-diaryl benzopyran analogues as novel selective cyclooxygenase-2 inhibitors • SHORT COMMUNICATION S. Prasanna, E. Manivannan and S. C. Chaturvedi SummaryPlus | Full Text + Links | PDF (335 K) | |||
|
Synthesis and structure–activity relationships of novel IKK- inhibitors. Part 2: Improvement of in vitro activity • SHORT COMMUNICATION Toshiki Murata, Mitsuyuki Shimada, Hiroshi Kadono, Sachiko Sakakibara, Takashi Yoshino, Tsutomu Masuda, Makoto Shimazaki, Takuya Shintani, Kinji Fuchikami, Kevin B. Bacon et al. SummaryPlus | Full Text + Links | PDF (265 K) | |||
|
Synthesis and structure–activity relationships of novel IKK- inhibitors. Part 3: Orally active anti-inflammatory agents • SHORT COMMUNICATION Toshiki Murata, Mitsuyuki Shimada, Sachiko Sakakibara, Takashi Yoshino, Tsutomu Masuda, Takuya Shintani, Hiroki Sato, Yuji Koriyama, Keiko Fukushima, Noriko Nunami et al. SummaryPlus | Full Text + Links | PDF (275 K) | |||
|
Synthesis and cytotoxicity of water soluble quaternary salt derivatives of camptothecin • SHORT COMMUNICATION Yuan-gang Zu, Qing-yong Li, Yu-jie Fu and Wei Wang SummaryPlus | Full Text + Links | PDF (266 K) | |||
|
The synthesis and SAR of 2-arylsulfanyl-phenyl piperazinyl acetic acids as glyT-1 inhibitors • SHORT COMMUNICATION Garrick Smith, Thomas Ruhland, Gitte Mikkelsen, Kim Andersen, Claus Tornby Christoffersen, Lene Hjorth Alifrangis, Arne Mørk, Stephen P. Wren, Neil Harris, Barry M. Wyman and Guillaume Brandt SummaryPlus | Full Text + Links | PDF (309 K) | |||
|
Defining determinant molecular properties for the blockade of the apamin-sensitive SKCa channel in guinea-pig hepatocytes: the influence of polarizability and molecular geometry • SHORT COMMUNICATION Dimitrios Galanakis and C. Robin Ganellin SummaryPlus | Full Text + Links | PDF (274 K) | |||
|
Novel thiophenes and analogues with anthelmintic activity against Haemonchus contortus • SHORT COMMUNICATION Isabel C. González, Leon N. Davis and Charles K. Smith, II SummaryPlus | Full Text + Links | PDF (296 K) | |||
|
Parallel synthesis and structure–activity relationships of a series of highly potent, selective, and neutral factor Xa inhibitors • SHORT COMMUNICATION Shawn M. Bauer, Erick A. Goldman, Wenrong Huang, Ting Su, Lingyan Wang, John Woolfrey, Yanhong Wu, Jingmei F. Zuckett, Ann Arfsten, Brian Huang et al. SummaryPlus | Full Text + Links | PDF (282 K) | |||
|
Synthesis of oligodeoxynucleotides containing a single diastereoisomer of -(N2-2′-deoxyguanosinyl)-N-desmethyltamoxifen • SHORT COMMUNICATION Y. R. Santosh Laxmi, Naomi Suzuki, Sung Yeon Kim and Shinya Shibutani SummaryPlus | Full Text + Links | PDF (282 K) | |||
|
Leishmanicidal activity of phenylene bridged C2 symmetric glycosyl ureides • SHORT COMMUNICATION Neetu Tewari, Ramesh, R. C. Mishra, R. P. Tripathi, V. M. L. Srivastava and Suman Gupta SummaryPlus | Full Text + Links | PDF (263 K) | |||
|
Change in liver and plasma ceramides during Miho Yamaguchi, Yayoi Miyashita, Yumi Kumagai and Shosuke Kojo SummaryPlus | Full Text + Links | PDF (246 K) | |||
|
Flow cytometric screening of aldolase catalytic antibodies • SHORT COMMUNICATION Hyunbo Shim, Amelie Karlström, Sofia M. Touami, Roberta P. Fuller and Carlos F. Barbas, III SummaryPlus | Full Text + Links | PDF (354 K) | |||
|
A novel series of 2-pyridyl-containing compounds as lysophosphatidic acid receptor antagonists: development of a nonhydrolyzable LPA3 receptor-selective antagonist • SHORT COMMUNICATION Brian H. Heasley, Renata Jarosz, Karen M. Carter, S. Jenny Van, Kevin R. Lynch and Timothy L. Macdonald SummaryPlus | Full Text + Links | PDF (302 K) | |||
|
Synthesis and antiviral activity of P1′ arylsulfonamide azacyclic urea HIV protease inhibitors • SHORT COMMUNICATION Peggy P. Huang, John T. Randolph, Larry L. Klein, Sudthida Vasavanonda, Tatyana Dekhtyar,Vincent S. Stoll and Dale J. Kempf SummaryPlus | Full Text + Links | PDF (320 K) | |||
|
Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodies • SHORT COMMUNICATION Michael L. Miller, Elizabeth E. Roller, Xinyaun Wu, Barbara A. Leece, Victor S. Goldmacher, Ravi V. J. Chari and Iwao Ojima SummaryPlus | Full Text + Links | PDF (283 K) | |||
|
Synthesis and biological evaluation of the major metabolite of atomoxetine: elucidation of a partial  -opioid agonist effect • SHORT COMMUNICATIONChristopher J. Creighton, Kris Ramabadran, Patrick E. Ciccone, Jingchun Liu, Michael J. Orsini and Allen B. Reitz SummaryPlus | Full Text + Links | PDF (248 K) | |||
|
Synthesis and cytotoxic activity of 3-O-acyl/3-hydrazine /2-bromo/20,29-dibromo betulinic acid derivatives • SHORT COMMUNICATION Rama Mukherjee, Manu Jaggi, Mohammad J. A. Siddiqui, Sanjay K. Srivastava, Praveen Rajendran, Anand Vardhan and Anand C. Burman SummaryPlus | Full Text + Links | PDF (267 K) | |||
|
Synthesis of new coumarin 3-(N-aryl) sulfonamides and their anticancer activity • SHORT COMMUNICATION Natala Srinivasa Reddy, Muralidhar Reddy Mallireddigari, Stephen Cosenza, Kiranmai Gumireddy, Stanley C. Bell, E. Premkumar Reddy and M. V. Ramana Reddy SummaryPlus | Full Text + Links | PDF (278 K) | |||
|
Structure–activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists • SHORT COMMUNICATION Rosa Arienzo, David E. Clark, Sue Cramp, Stephen Daly, Hazel J. Dyke, Peter Lockey, Dennis Norman, Alan G. Roach, Keith Stuttle, Maxine Tomlinson et al. SummaryPlus | Full Text + Links | PDF (248 K) | |||
|
Fluorinated quinoid inhibitor: possible ‘pure' arylator predicted by the simple theoretical calculation • SHORT COMMUNICATION Seung Wook Ham, Jong-In Choe, Mei-Fang Wang, Vincent Peyregne and Brian I. Carr SummaryPlus | Full Text + Links | PDF (259 K) | |||
|
Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents • SHORT COMMUNICATION Ahmed Kamal, O. Srinivas, P. Ramulu, G. Ramesh and P. Praveen Kumar SummaryPlus | Full Text + Links | PDF (275 K) | |||
|
Editorial board • MISCELLANEOUS PDF (220 K) | |||
|
Contributors to this issue • MISCELLANEOUS PDF (191 K) | |||
|
Instructions to contributors • PUBLISHER'S NOTE PDF (74 K) | |||
|
|
|
|
|
|
| Copyright © 2004 Elsevier B.V. All rights reserved. ScienceDirect® is a registered trademark of Elsevier B.V. |
